Séminaire du 14/03/2018, 14h00

mercredi 14 mars 2018, 14h00

Mechanobiology of aortic aneurysms: novel approach using finite-element modeling and multimodality imaging

Conférenciers : Stéphane Avril (U1059 INSERM - SAINBIOSE)

Histopathological changes that occur in diseased soft tissues manifest at the macroscopic level as altered mechanical functionality and structural integrity. Correlations between local tissue composition and mechanical properties can thus provide increased insight into conditions that render a soft tissue susceptible to failure or disease. Toward this end, we have used the virtual fields method to determine locally varying values of constitutive parameters from a set of full-field data acquired during tension-inflation tests of arteries using a combination of panoramic digital image correlation (p-DIC) and of optical coherence tomography - digital volume correlation (OCT-DVC). The approach has permitted to reveal for the first time the local material heterogeneities of aortic aneurysms and to relate them to the biological dysfunctions that render blood vessels susceptible to potential rupture.